NMN is a popular supplement in the longevity circles. But can it boost height gain? IT’s also possible that Niacin supplementation could increase if NMN can as Niacin and NMN are related. NMN is derived from Niacin and NMN is part of the Vitamin B3 family. But NMN likely only will increase height if taken early in development but it is also possible that NMN will only increase height if one is deficient.
Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling
“Sirtuin 6 (Sirt6) is a mammalian homologue of NAD1-dependent histone deacetylase Sir2. Although
Sirt6-KO mice exhibit growth retardation”
“In Sirt6-KO mice exhibited impaired proliferation and differentiation of chondrocytes, reduced expression of Indian hedgehog (Ihh), and a senescent phenotype. When Sirt6 was knocked down in chondrocytes in vitro, expression of Ihh and its downstream genes were reduced.”
“stress-response and chromatin-silencing factor Sir2, a yeast sirtuin, is a NAD1-dependent histone
deacetylase and is involved in various nuclear actions”
“Sirt6 inhibits inflammation by suppressing NF-kB target molecules via interaction with the RelA subunit of NF-kB and by deacetylating H3K9 at target promoters”
“Sirt6–null mice exhibit dwarfism”
Here’s the part of the study about NMN:
“to study the effect of gain of Sirt6 activity on chondrocyte differentiation, nicotinamide mononucleotide (NMN), a key NAD1 intermediate, was administered to ATDC5 cells. NMN facilitates
activity of sirtuins through enhancement of NAD biosynthesis. NMN administration enhanced Col10a1 expression together with increased expression of Ihh and Gli1, and these effects were clearly
abrogated by Sirt6 silencing”
“NMN treatment enhanced Col10a1, Ihh and Gli1”
This study here:
Nicotinamide Mononucleotide Alleviates Osteoblast Senescence Induction and Promotes Bone Healing in Osteoporotic Mice
says that NMN can “NMN supplementation attenuates senescent cell induction in growth plates”<- so it’s possible NMN can keep the growth plates open for longer. Couldn’t get the full study though.
Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow
“NMN supplementation stimulated osteogenesis of endogenous MSCs, and protected bone from aging and irradiation induced damage in mice. Mechanistically, we found that NMN treatment upregulated SIRT1”
It should be noted that NMN is available in foods and laboratory animals tend not to have the most diverse diets. So we don’t know if enough NMN is gotten from foods.
Source link
